Understanding WordPress Multisite →
This quick tutorial video from Tuts+ shows you how to install a multisite, a WordPress feature that allows users to create a network of sites on a single WordPress installation. Setup is a matter of copy and pasting some code into the right places. Once your site is multisite ready you can do things like run a network of multiple WordPress blogs, subdomains like http://john.example.com, or directories like http://www.example.com/john/.